We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Investigation of the protective effects of Aloe barbadensis miller plant juicy extract on glutamate toxicity.
- Authors
Yılmaz, Ayşegül; Taghizadehghalehjoughi, Ali; Hacımüftüoğlu, Ahmet
- Abstract
Objective: Although it is known that the aloe vera family has protective effects on the neuron, it has not been studied on the neuron protective effect of Aloe barbadensis miller plant. In this study, it is aimed to investigate protective effects of Aloe barbadensis miller plant on glutamate toxicity model formed in cortex neuron culture by isolating the water extract. Methods: Neuron cortex cells were obtained from medical pharmacology department of atatürk university medical faculty. Aloe barbadensis miller plant extract was obtained from Nurbal, Istanbul. The plant juicy extract was used at doses of 25, 50, '00, 200, 400, 800 and '600 micrograms (pg), and glutamate at '0-5 mM. The adjusted doses were applied to the neuron cortex cells and read at a wavelength of 570 nm after 24 hours of treatment. 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) results were analyzed by one way ANOVA method in SPSS, IBM 2'.00 program. Results: In our control group, the vitality was defined as '00% and the other groups were rated accordingly. Glutamate '0-5 mM group showed the least viability rate with 59% (p<0.00'). In aloe barbadensis, it was observed that the viability did not increase with dose and the highest vitality rate was between '00 and 400 pg (93%-89%). When compared with our control group, the lowest vitality rate was observed in 25pg (6'%) (p<0.00'). Conclusion: We observed that Aloe vera barbadensis protects neurons against glutamate toxicity at doses of '00 and 400 pgr.
- Subjects
ALOE vera; PLANT extracts; GLUTAMIC acid; INTERNATIONAL Business Machines Corp.; FACULTY-college relationship; ACADEMIC departments
- Publication
Anatomy: International Journal of Experimental & Clinical Anatomy, 2019, Vol 13, Issue S1, pS70
- ISSN
1307-8798
- Publication type
Article