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- Title
Pulmonary Rehabilitation Associated with Noninvasive Ventilation on Physical Capacity and Quality of Life in Post-COVID-19: A Randomized Controlled Double-Blinded Clinical Trial Protocol.
- Authors
Arêas, Guilherme Peixoto Tinoco; da Luz Goulart, Cássia; Sant'Anna, Thaís; Fernandes, Tiótrefis Gomes; de Oliveira Alvim, Rafael; Borges, Fernanda Facioli dos Reis; Amaral, Camila Miriam Suemi Sato Barros do; Rodrigues, Suzy Cristina França; Valente, Jefferson; Ferreira, João Marcos Bemfica Barbosa; Rezende, Anna Gabriela; de Oliveira Júnior, Edival Ferreira; Lacerda, Marcus Vinícius Guimarães de; de Almeida-Val, Fernando Fonseca
- Abstract
To compare the use of a noninvasive ventilation (NIV) plus aerobic exercise strategy during PR program with to a standard PR (without NIV) on physical capacity and quality of life outcomes in post-COVID-19. Methods: Double-blinded randomized controlled clinical trial. A total of 100 individuals discharged from hospital in a post-acute phase of severe COVID-19 will be randomized into two groups: PR + NIV (Group 1) and PR (Group 2). Inclusion criteria include participants who present symptomatic dyspnea II and III by the modified Medical Research Council, aged 18 years or older. Both groups will receive aerobic and resistance exercise, and inspiratory muscle training. However, group 1 will perform aerobic training with bilevel NIV. Cardiopulmonary exercise test will assess the O2 peak uptake, 6-minute walk test will assess the walking distance and short-form 36 will assess the quality of life before and after 8 weeks (after 24 PR sessions). Moreover, patients will be contacted by telephone every 3 months for one year to record possible adverse events, hospitalizations, and death. All data will be registered in RedCap, and analyses will be performed in the STATA v13 software. Clinical Trial Registration: RBR-3t9pkzt.
- Subjects
CLINICAL trials; MEDICAL Research Council (Great Britain); NONINVASIVE ventilation; MEDICAL protocols; COVID-19 pandemic; QUALITY of life
- Publication
Journal of Multidisciplinary Healthcare, 2024, Vol 17, p1483
- ISSN
1178-2390
- Publication type
Article
- DOI
10.2147/JMDH.S438120