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- Title
ANALYSIS OF VARIATION OF SERUM CEA, SCO, CYFRA21-1 IN PATIENTS WITH LUNG CANCER AND THEIR DIAGNOSTIC VALUE WITH EBUS-TBNA.
- Authors
YanJia Du; Ya Wen; JieYu Huang
- Abstract
Background: To explore the variation of serum carcinoem-bryonic antigen (CEA), cytokeratin 19 fragment (CYFRA21-1), and squamous cell carcinoma (SCC) antigen in patients with lung cancer (LC) and their diagnostic value with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Methods: This study examined the diagnostic value of serum tumor marker testing and EBUS-TBNA joint detection for LC in 150 patients with suspected LC. Results: Compared to benign patients, the serum levels of CYFRA21-1, SCC, and CEA in LC were higher (P<0.05). In patients with squamous cell carcinoma (LSCC), small cell lung cancer (SCLC), and lung adenocarcinoma, lung adenocarcinoma had higher serum CEA levels (P<0.05). In comparison, LSCC patients had higher serum SCC and CYFRA21-1 levels (P<0.05). As compared to each index detected alone, the AUC of combined detection of each index to diagnose LC and identify pathological types of LC was elevated. Conclusions: The clinical significance of serum CYFRA21-1, SCC, and CEA conjugated with EBUS-TBNA is demonstrated for diagnostic purposes and identification of LC pathological types.
- Subjects
LUNG cancer; CANCER patients; LUNGS; SMALL cell lung cancer; NEEDLE biopsy; BLOOD serum analysis; SERUM
- Publication
Journal of Medical Biochemistry, 2024, Vol 43, Issue 3, p363
- ISSN
1452-8258
- Publication type
Article
- DOI
10.5937/jomb0-37083