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- Title
Role of MicroRNA-122 in Predicting Chronic Liver Diseases among Iraqi Patients with HCV.
- Authors
Abd Al Reda, Leena Falh; Dawood, Dawood Salman; Najeeb, Akram Ajeel
- Abstract
MicroRNAs is play important roles in liver pathologies, including hepatitis, liver cirrhosis, and liver cancer. miRNA-122 is a liver-specific. This study aimed to determine the expression level of miRNA-122 in the plasma as a diagnostic marker of liver injury and the ratio of HCV genotype in Iraqi patients. A total of 80 participants who divided into; Group I included 35 patients with CHC infection, Group II included 20 patients with (cirrhosis &HCC) and Group III included 25 healthy control. HCV Genotype and miRNA-122 in the plasma were measured using real-time PCR. This study showed that the mean Log fold of miRNA-122 was higher in CHC group as comparison to controls while in the (cirrhosis&HCC) groups was non-significant in compared with controls. Moreover, the most prevalence genotype 4 then 1a. In conclusion measurements of miRNA-122 may be useful in the evaluation of HCV patients.
- Publication
Indian Journal of Public Health Research & Development, 2019, Vol 10, Issue 4, p1532
- ISSN
0976-0245
- Publication type
Article
- DOI
10.5958/0976-5506.2019.00933.1