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- Title
Effect of vitamin D3 supplementation on TNF-α serum level and disease activity index in Iranian IBD patients.
- Authors
Dadaei, Tahereh; Safapoor, Mohammad Hosein; Aghdaei, Hamid Asadzadeh; Balaii, Hedie; Pourhoseingholi, Mohammad Amin; Naderi, Nosratollah; Zojaji, Homayoon; Azimzadeh, Pedram; Mohammadi, Parvaneh; Zali, Mohammad Reza
- Abstract
Aim: The aim of the study was to assess the effectiveness of vitamin D3 [1, 25(OH)2D3] treatment in IBD with regard to tumor necrosis factor-alpha (TNF-α) serum level and clinical disease activity index (CDAI). Background: Vitamin D has immune-regulatory functions in experimental inflammatory bowel disease (IBD) and vitamin D deficiency is common in IBD patients. Patients and methods: This was a randomized clinical trial on 108 IBD patients with serum 25-OHD levels less than 30ng/ml, which divided into vitamin D and control groups. Vitamin D group received 50000 IU vitamin D3 for 12 weeks. Before and after the study, TNF-α and 25-OHD serum levels were measured by ELISA method. Data were analyzed using paired t-test, chi-square test and Spearman correlation coefficient. P-values less than 0.05 were considered statistically significant. Results: Before the intervention no significant difference was found between baseline characteristics and TNF-α serum level of two groups. After intervention TNF-α serum level reduced but this reduction was not statistically significant (p= 0.07, 95% CI: -0.45 to 8.14). The mean serum 25-OHD level of vitamin D increased from 15.54 to 67.89, which was statistically significant (p= 0.00, 95% CI: -61.40 to -43.30). TNF-α level was also associated significantly with CDAI before (Spearman's rho: 0.3, p<0.0001) and after (Spearman's rho: 0.27, P=0.01) intervention. Conclusion: Oral supplementation vitamin D3 significantly increased serum vitamin D levels and insignificantly reduced serum TNF-α level. More studies with larger samples would be beneficial to assess vitamin D3 supplementation efficient effect in IBD.
- Subjects
INFLAMMATORY bowel disease treatment; CHI-squared test; CONFIDENCE intervals; GASTROENTEROLOGY; INFLAMMATORY bowel diseases; MEDICAL care; PATIENTS; STATISTICS; T-test (Statistics); TUMOR necrosis factors; VITAMIN D; DATA analysis; RANDOMIZED controlled trials; DESCRIPTIVE statistics
- Publication
Gastroenterology & Hepatology from Bed to Bench, 2015, Vol 8, Issue 1, p49
- ISSN
2008-2258
- Publication type
Article