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- Title
Comparative Effectiveness of Fecal Immunochemical Tests versus Flexible Sigmoidoscopy for Colorectal Cancer Screening: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
- Authors
Mutneja, Hemant Raj; Agrawal, Rohit; Bhurwal, Abhishek; Arora, Shilpa; Go, Andrew; Attar, Bashar M.
- Abstract
Background & Aims: Fecal immunochemical tests (FITs) and flexible sigmoidoscopies are commonly used modalities for colorectal cancer (CRC) screening. We performed a systematic review and meta-analysis to compare the effectiveness of FIT and sigmoidoscopy in CRC screening. Methods: PRISMA statement and Cochrane guidelines were followed for this review. Digital dissertation databases were searched from inception till December 1st 2020 and randomized clinical trials comparing the detection rates of CRC for FIT and sigmoidoscopy were included. Outcomes for analysis included participation rates and detection rates of CRC, advanced adenomas and advanced colorectal neoplasia for both screening modalities. Methods: PRISMA statement and Cochrane guidelines were followed for this review. Digital dissertation databases were searched from inception till December 1st 2020 and randomized clinical trials comparing the detection rates of CRC for FIT and sigmoidoscopy were included. Outcomes for analysis included participation rates and detection rates of CRC, advanced adenomas and advanced colorectal neoplasia for both screening modalities. Conclusion: Despite lower participation amongst patients, CRC screening with flexible sigmoidoscopy leads to higher detection of advanced colorectal neoplasia, when compared to a single round of fecal immunochemical testing.
- Subjects
SIGMOIDOSCOPY; FECAL occult blood tests; COLORECTAL cancer; CLINICAL trials; EARLY detection of cancer; ADENOMA; DATABASE searching
- Publication
Journal of Gastrointestinal & Liver Diseases, 2021, Vol 30, Issue 2, p267
- ISSN
1841-8724
- Publication type
Article
- DOI
10.15403/jgld-3432