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- Title
Contributions of M- and Persistent Sodium Currents in Regulating Locomotor Rhythms: A Computational Modeling Study.
- Authors
Zhu, Qinghua; Wang, Fengjie; Han, Fang
- Abstract
Physiological experiments have demonstrated that M-current ( I M ) and persistent sodium current ( I NaP ) expressed in rhythm-generating neurons play a key role in the generation and regulation of locomotor rhythms. However, the intrinsic mechanisms by which these two ionic currents control the locomotor rhythms are poorly understood. Here, a computational model is constructed to investigate the roles of I M and I NaP in regulating locomotor rhythms and explain the underlying ionic mechanisms. The simulation results show that decreasing I M or increasing I NaP facilitates the generation of the bursting activity; during the bursting activity, the burst frequency of the model has a positive dependence on I M , and the flexion-extension as well as left-right coordination are not affected by varying I M . These results accurately reproduce the experimental results. In addition, the results also show that the dependence of burst frequency- I NaP is similar to that of burst frequency- I M , but with distinct regulation mechanisms, i.e. I M regulates the burst frequency by affecting the burst and interburst durations, whereas I NaP regulates the burst frequency via manipulating the interburst duration. Finally, a dynamical analysis is given to reveal the intrinsic neural mechanisms of I M and I NaP in regulating the burst properties. Our study provides new insights into how outward and inward currents work in tandem to set the speed of locomotion, and provides testable predictions for biological experimental studies.
- Subjects
LOCOMOTOR control; RHYTHM; SODIUM; SODIUM channels
- Publication
International Journal of Bifurcation & Chaos in Applied Sciences & Engineering, 2023, Vol 33, Issue 12, p1
- ISSN
0218-1274
- Publication type
Article
- DOI
10.1142/S0218127423501432