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- Title
The activation of β-catenin by Gαs contributes to the etiology of phenotypes seen in Fibrous dysplasia and McCune-Albright syndrome.
- Authors
Zhong, Zhendong; Williams, Bart O; Steensma, Matthew R
- Abstract
The authors discuss aspects of the contribution of β-catenin activation by Gαs to the etiology of phenotypes in McCune-Albright syndrome and fibrous dysplasia (FD). They are critical on the condition of FD to the enhanced proliferation of osteoblast precursors with terminal differentiation failure. Also investigated is the significant morbidity effect on the structural alterations in FD including limb-length discrepancies, angular deformity and fracture.
- Subjects
FIBROUS dysplasia of bone; CELL transformation; CELLULAR pathology; ETIOLOGY of diseases; ABNORMALITIES in the anatomical extremities; THERAPEUTICS
- Publication
IBMS BoneKEy, 2012, Vol 9, Issue 6, p113
- ISSN
1940-8692
- Publication type
Article
- DOI
10.1038/bonekey.2012.113