We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
β-Lapachone suppresses the lung metastasis of melanoma via the MAPK signaling pathway.
- Authors
Kee, Ji-Ye; Han, Yo-Han; Kim, Dae-Seung; Mun, Jeong-Geon; Park, Seong-Hwan; So, Hong-Seob; Park, Sung-Joo; Park, Raekil; Um, Jae-Young; Hong, Seung-Heon
- Abstract
β-Lapachone is a natural quinone compound from Lapacho trees, which has various pharmacological effects such as anti-bacterial, anti-fungal, anti-viral, and anti-inflammatory activities. However, the effect of β-lapachone on metastasis of melanoma cells is unclear. In this study, β-lapachone reduced cell viability of metastatic melanoma cancer cell lines B16F10 and B16BL6 through induction of apoptosis via the mitogen-activated protein kinase (MAPK) pathway. Additionally, flow cytometry results showed that β-lapachone increased DNA content in the G0/G1 phase of the cell cycle. Analysis of the mechanisms of these events indicated that β-lapachone regulated the expression of Bcl-2, Bcl-xL, and Bax, resulting in the activation of caspase-3, -8, -9, and poly-ADP-ribose polymerase (PARP). Moreover, the β-lapachone-administered group showed significantly decreased lung metastasis in the experimental mouse model. In conclusion, our study demonstrates the inhibitory effect of β-lapachone on lung metastasis of melanoma cells and provides a new insight into the role of β-lapachone as a potential antitumor agent.
- Subjects
LUNG cancer; MITOGEN-activated protein kinases; CELLULAR signal transduction; QUINONE compounds; INFLAMMATION
- Publication
PLoS ONE, 2017, Vol 12, Issue 5, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0176937